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Structural Biology Center - Home of the High Throughput Screening Laboratory
We strongly believe that high throughput screening (HTS) technology needs to play an increasing and major role in academic research to enable academic researchers to identify biological probes and to provide leads for drug discovery aimed at orphan diseases. In order to make this technology available to biomedical researchers in Kansas, the Greater Kansas City area and beyond, an HTS facility was proposed as one of two core facilities in the NIH Grant (P20 RR015563, Timmermann, PI) from the COBRE Program of the NCRR. The HTS facility at the University of Kansas (KU) began operations at the end of 2002 with the acquisition of 100,000 drug-like small molecules and the installation of a fully automated screening system. Currently we are developing screening capabilities for diverse biochemical and cell-based assays.
The University of Kansas dedicated the first level of the new Structural Biology Center (2121 Simons Drive, Lawrence, KS 66047) to the core facilities of this COBRE grant. The space includes three laboratories, four offices and two open office areas. The laboratories house the Beckman ORCA Robot/Biomek FX liquid handling system, a 300 MHz NMR, a MicroMass Quattro MS spectrophotometer, and other general equipment for biomedical and medicinal chemistry research.
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