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We strongly believe that high throughput screening (HTS) technology needs to play an increasing and major role in academic research to enable academic researchers to identify biological probes and to provide leads for drug discovery aimed at orphan diseases. In order to make this technology available to biomedical researchers in Kansas, the Greater Kansas City area and beyond, an HTS facility was proposed as one of two core facilities in the NIH Grant (P20 RR015563, Timmermann, PI) from the COBRE Program of the NCRR. The HTS facility at the University of Kansas (KU) began operations at the end of 2002 with the acquisition of 100,000 drug-like small molecules and the installation of a fully automated screening system. Currently we are developing screening capabilities for diverse biochemical and cell-based assays.
The University of Kansas dedicated the upper level of building C (6,500 sq. ft.) of the Life Sciences Research Laboratories (LSRL, 1501 Wakarusa Dr.) to the core facilities of this COBRE grant. The space includes eight laboratories, five offices and an open office area. The laboratories house the Beckman ORCA Robot/Biomek FX liquid handling system, a 300 MHz NMR, a MicroMass Quattro MS spectrophotometer, and other general equipment for biomedical and medicinal chemistry research.
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